期刊
FEMS MICROBIOLOGY LETTERS
卷 286, 期 1, 页码 66-70出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1574-6968.2008.01253.x
关键词
respiratory chain; quinone; peroxidase; oxidative stress; Aggregatibacter actinomycetemcomitans; leukotoxin
类别
资金
- Japan society for the Promotion of Science [19791353]
Aggregatibacter actinomycetemcomitans is an oral pathogen causing localized aggressive periodontitis (LAP). Recently, we characterized for the first time a quinol peroxidase (QPO) that catalyzes peroxidase activity using quinol ill the respiratory chain of A. actinomycetemcomitans for the reduction of hydrogen peroxide. In the present study, we characterized the phenotype of a QPO null mutant. The QPO null mutant shows an oxidative stress phenotype, suggesting that QPO plays a certain role in scavenging endogenously generated reactive oxygen species. Notably, we discovered that the QPO null mutant exhibits a production defect of leukotoxin (LtxA), which is a secreted bacterial toxin and is known to target human leukocytes and erythrocytes. This result suggests that QPO would be considered as a potential drug target to inhibit the expression of LtxA from A. actinomycetemcomitans for the treatment and prevention of LAP.
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