期刊
FEMS MICROBIOLOGY LETTERS
卷 289, 期 2, 页码 146-154出版社
OXFORD UNIV PRESS
DOI: 10.1111/j.1574-6968.2008.01379.x
关键词
carbon catabolite repression; chromatin; Aspergillus nidulans; RcoA; SsnF
类别
资金
- Spanish Ministry of Education
- EU [BIO4-CT96-0535]
- Universite Paris-Sud
- CNRS
- IUF
For three different carbon catabolite repressible promoters, alcA, alcR and the bidirectional promoter prnD-prnB, a deletion of rcoA, the Aspergillus nidulans homologue of TUP1, does not result in carbon catabolite derepression. Surprisingly, it results in disruption of the chromatin default structure of alcR and prnD-prnB promoters. In these promoters, and at variance with the wild type, repression occurs in the absence of nucleosome positioning. For alcR, repression occurs together with a nucleosome pattern identical to that found under conditions of full expression, and for prnD-prnB it occurs with a novel pattern that does not correspond to the pattern seen under conditions of repression in a wild-type strain. Deletion of the putative RcoA partner, SsnF, is lethal in A. nidulans.
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