期刊
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY
卷 66, 期 2, 页码 220-229出版社
WILEY
DOI: 10.1111/j.1574-695X.2012.01005.x
关键词
Staphylococcus aureus; staphylococcal virulence factors; extracellular staphylococcal proteases; sernine protease-like proteins; antistaphylococcal immune response
资金
- Polish Ministry of Science and Higher Education and by the Jagiellonian University [N N302 130734, N N301 032834, DS/9/WBBiB]
- European Union [POIG.02.01.00-12-064/08, POIG.02.01.00-12167/08]
Proteases of Staphylococcus aureus have long been considered to function as important virulence factors, although direct evidence of the role of particular enzymes remains incomplete and elusive. Here, we sought to provide a collective view of the prevalence of extracellular protease genes in genomes of commensal and pathogenic strains of S.aureus and their expression in the course of human and mouse infection. Data on V8 protease, staphopains A and B, aureolysin, and the recently described and poorly characterized group of six Spl proteases are provided. A phylogenetically diverse collection of 167 clinical isolates was analyzed, resulting in the comprehensive genetic survey of the prevalence of protease-encoding genes. No correlation between identified gene patterns with specific infections was established. Humoral response against the proteases of interest was examined in the sera derived from human patients and from a model mouse infection. The analysis suggests that at least some, if not all, tested proteases are expressed and secreted during the course of infection. Overall, the results presented in this study support the hypothesis that the secretory proteases as a group may contribute to the virulence of S.aureus.
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