期刊
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY
卷 65, 期 2, 页码 381-384出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1574-695X.2012.00942.x
关键词
biofilms; biofilm eradication; nonthermal plasma; atmospheric pressure plasma; plasma medicine
资金
- University of Jordan
- EPSRC [EP/H003797/1]
- Engineering and Physical Sciences Research Council [EP/H003797/2, EP/H003797/1, EP/I500987/1] Funding Source: researchfish
- EPSRC [EP/H003797/1, EP/I500987/1, EP/H003797/2] Funding Source: UKRI
The use of atmospheric pressure nonthermal plasma represents an interesting and novel approach for the decontamination of surfaces colonized with microbial biofilms that exhibit enhanced tolerance to antimicrobial challenge. In this study, the influence of an atmospheric pressure nonthermal plasma jet, operated in a helium and oxygen gas mixture under ambient pressure, was evaluated against biofilms of Bacillus cereus,Staphylococcus aureus,Escherichia coli and Pseudomonas aeruginosa. Within < 4 min of plasma exposure, complete eradication of the two Gram-positive bacterial biofilms was achieved. Although Gram-negative biofilms required longer treatment time, their complete eradication was still possible with 10 min of exposure. Whilst this study provides useful proof of concept data on the use of atmospheric pressure plasmas for the eradication of bacterial biofilms in vitro, it also demonstrates the critical need for improved understanding of the mechanisms and kinetics related to such a potentially significant approach.
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