期刊
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY
卷 65, 期 1, 页码 121-124出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1574-695X.2012.00941.x
关键词
Candida albicans; ALS gene family; cell surface engineering; biofilm; plastic; metal
资金
- Japan Society for the Promotion of Science [22-101]
- Grants-in-Aid for Scientific Research [23658074, 09J02920, 10J00101] Funding Source: KAKEN
Candida albicans is normally present in nearly all humans but can cause fatal diseases in immunocompromised patients. The agglutinin-like sequence (ALS) gene family of C.similar to albicans has been suggested to be important for biofilm formation on medical devices. Here, we cloned all ALS genes and determined the binding properties of their gene products by cell surface engineering of Saccharomyces cerevisiae. Most of the ALS homologues had the ability to bind polypropylene, borosilicate glass and polyvinyl chloride, which are often used as materials in medical devices. However, ALS homologues were not able to bind polyurethane, polymethyl methacrylate, polytetrafluoroethylene or titanium. These findings will aid in the development of biofilm-resistant medical devices.
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