期刊
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY
卷 66, 期 3, 页码 273-280出版社
WILEY
DOI: 10.1111/j.1574-695X.2012.01002.x
关键词
tuberculosis; purified protein derivative; tuberculin skin test; diagnosis
资金
- Tuberculosis Vaccine Testing and Research Materials contract from the NIH
The tuberculin skin test, which involves monitoring the immune reaction to an injection of purified protein derivative (PPD), has been the most widely used method for detecting infection with Mycobacterium tuberculosis since its development in 1930s. Until recently, the molecular composition of PPD was unknown. This thwarted the discovery of improved skin testing reagents and drastically hindered efforts to define the mechanism of action. Proteomic evaluation of PPD combined with a detailed analysis in the guinea pig model of tuberculosis led to further definition of the molecular composition of PPD. This communication reviews the history and current status of PPD, in addition to describing candidate next-generation PPD reagents, based on the use of an individual protein or protein cocktails.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据