期刊
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY
卷 65, 期 2, 页码 146-157出版社
WILEY
DOI: 10.1111/j.1574-695X.2011.00858.x
关键词
biofilm; resistance; attachment; development; inhibition; dispersion
资金
- Danish Council for Independent Research [09-073917]
- Novo Nordisk Fonden [NNF10CC1016517] Funding Source: researchfish
Biofilms are complex microbial communities consisting of microcolonies embedded in a matrix of self-produced polymer substances. Biofilm cells show much greater resistance to environmental challenges including antimicrobial agents than their free-living counterparts. The biofilm mode of life is believed to significantly contribute to successful microbial survival in hostile environments. Conventional treatment, disinfection and cleaning strategies do not proficiently deal with biofilm-related problems, such as persistent infections and contamination of food production facilities. In this review, strategies to control biofilms are discussed, including those of inhibition of microbial attachment, interference of biofilm structure development and differentiation, killing of biofilm cells and induction of biofilm dispersion.
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