期刊
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY
卷 61, 期 1, 页码 129-132出版社
WILEY
DOI: 10.1111/j.1574-695X.2010.00759.x
关键词
interleukin-17A; interleukin-23; gonorrhoea
资金
- 'Controllo delle infezioni nei soggetti deboli ed immunocompromessi-agenti opportunistici e nuove opportunita di controllo delle infezioni' Collaborating Project Italy-USA, Ministry of Health [Fasc.28C6, 2008-2010]
Neisseria gonorrhoeae is the etiological agent of gonorrhoea, an infectious disease characterized by acute inflammation of the urogenital tract with a massive infiltration of neutrophils. Polymorphonuclear leukocyte recruitment is one of the activities of the recently described interleukin-17A (IL-17A); thus, we analyzed the serum concentration of IL-17A, together with IL-23 and interferon-gamma (IFN-gamma), in 27 patients with gonorrhoea. The concentration of these cytokines in patients' sera was significantly higher than that detected in healthy controls and an inverse correlation was found between the concentrations of IL-17A and IFN-gamma. This is the first report showing a significant increase of IL-17A and IL-23 serum levels in patients with gonorrhoea, suggesting new players in the immune response to N. gonorrhoeae.
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