期刊
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY
卷 56, 期 1, 页码 1-8出版社
WILEY
DOI: 10.1111/j.1574-695X.2009.00537.x
关键词
Helicobacter pylori; asthma; allergy; cytokines; chemokines; immune modulation
资金
- Ente Cassa di Risparmio di Firenze
- Istituto Superiore di Sanita
- Ministry of Health
- Ministry of University and Scientific Research
- University of Florence
- University of Padua (Progetto di Ateneo)
- Associazione Italiana per la Ricerca sul Cancro (AIRC)
Bronchial asthma and allergic diseases are orchestrated by T-cells producing T-helper type 2 (Th2) cytokines, such as interleukin-4 (IL-4) and IL-5, and are inhibited by Th1 responses. Helicobacter pylori has chronically infected the human population for c. 100000 years and preferentially elicits a Th1 mucosal immune response with the production of interferon-gamma and IL-12. Among several bacterial factors, the neutrophil-activating protein of H. pylori (HP-NAP) not only plays a key role in driving Th1 inflammation but it is also able to inhibit Th2 responses in vitro and in vivo in allergic bronchial asthma, in humans and mice. Both systemic and mucosal administrations of HP-NAP are successful in reducing eosinophilia, immunoglobulin E and systemic Th2 cytokines at the bronchial level. Thus, these results identify HP-NAP as a candidate for novel strategies for the prevention and treatment of allergic diseases.
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