期刊
FEBS LETTERS
卷 592, 期 16, 页码 2693-2705出版社
WILEY
DOI: 10.1002/1873-3468.13208
关键词
Actinobacteria; ADP-ribosylating toxins; Austwickia; diphtheria toxin; evolution; Streptomyces
资金
- NSERC
- CIHR [366017]
- Government of Ontario
Diphtheria toxin (DT), produced by Corynebacterium diphtheria, is the causative agent of diphtheria and one of the most potent protein toxins known; however, it has an unclear evolutionary history. Here, we report the discovery of a DT-like gene family in several bacterial lineages outside of Corynebacterium, including Austwickia and Streptomyces. These DT-like genes form sister lineages in the DT phylogeny and conserve key DT features including catalytic and translocation motifs, but possess divergent receptor-binding domains. DT-like genes are not associated with corynephage, but have undergone lateral transfer through a separate mechanism. The discovery of the first non-Corynebacterium homologs of DT sheds light on its evolutionary origin and highlights novelties that may have resulted in the emergence of DT targeting humans.
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