期刊
FEBS LETTERS
卷 588, 期 17, 页码 3111-3116出版社
WILEY
DOI: 10.1016/j.febslet.2014.05.066
关键词
NhaA; Cation/proton antiport; Solid supported membrane; Helicobacter pylori; Escherichia coli; Salmonella typhimurium
资金
- Deutsche Forschungsgemeinschaft [SFB 807, SFB 746]
- Excellence Initiative of the German Federal and State Governments [EXC 294]
- European Community's Seventh Framework Programme FP7, EDICT Consortium [HEALTH-F4-2007-201924]
Bacteria have adapted their NhaA Na+/H+ exchangers responsible for salt homeostasis to their different habitats. We present an electrophysiological and kinetic analysis of NhaA from Helicobacter pylori and compare it to the previously investigated exchangers from Escherichia coli and Salmonella typhimurium. Properties of all three transporters are described by a simple model using a single binding site for H+ and Na+. We show that H. pylori NhaA only has a small acidic shift of its pH-dependent activity profile compared to the other transporters and discuss why a more drastic change in its pH activity profile is not physiologically required. (C) 2014 The Authors. Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
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