期刊
FEBS LETTERS
卷 588, 期 23, 页码 4297-4304出版社
WILEY
DOI: 10.1016/j.febslet.2014.09.001
关键词
Transfer RNA; tRNA-derived fragment; RNA processing; Angiogenin; Stress; Apoptosis
资金
- NCI NIH HHS [R01 CA168872] Funding Source: Medline
Transfer RNA (tRNA) is traditionally considered to be an adaptor molecule that helps ribosomes to decode messenger RNA (mRNA) and synthesize protein. Recent studies have demonstrated that tRNAs also serve as a major source of small non-coding RNAs that possess distinct and varied functions. These tRNA fragments are heterogeneous in size, nucleotide composition, biogenesis and function. Here we describe multiple roles that tRNA fragments play in cell physiology and discuss their relevance to human health and disease. (C) 2014 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
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