期刊
FEBS LETTERS
卷 588, 期 19, 页码 3564-3570出版社
WILEY
DOI: 10.1016/j.febslet.2014.06.013
关键词
Nanopores; DNA origami; Self-assembly; Single molecule; Nanotechnology
资金
- EPSRC NanoDTC program
- EPSRC doctoral prize award
- ERC starting Grant
Nanopores have emerged over the past two decades to become an important technique in single molecule experimental physics and biomolecule sensing. Recently DNA nanotechnology, in particular DNA origami, has been used for the formation of nanopores in insulating materials. DNA origami is a very attractive technique for the formation of nanopores since it enables the construction of 3D shapes with precise control over geometry and surface functionality. DNA origami has been applied to nanopore research by forming hybrid architectures with solid state nanopores and by direct insertion into lipid bilayers. This review discusses recent experimental work in this area and provides an outlook for future avenues and challenges. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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