期刊
FEBS LETTERS
卷 588, 期 8, 页码 1480-1490出版社
WILEY
DOI: 10.1016/j.febslet.2014.02.002
关键词
Gastrointestinal system; Nitric oxide; Nitric oxide synthase; Immunofluorescence; EGFP reporter; Connexin36 knockout
资金
- Natural Science and Engineering Research Council [RGPIN 436390-2013]
- Manitoba Health Research Council
- Canada Foundation for Innovation
- Canadian Institutes of Health Research [MOP 106598]
- National Institutes of Health [NS31027, NS44010, NS44295]
Neurons in the enteric nervous system utilize numerous neurotransmitters to orchestrate rhythmic gut smooth muscle contractions. We examined whether electrical synapses formed by gap junctions containing connexin36 also contribute to communication between enteric neurons in mouse colon. Spontaneous contractility properties and responses to electrical field stimulation and cholinergic agonist were altered in gut from connexin36 knockout vs. wild-type mice. Immunofluorescence revealed punctate labelling of connexin36 that was localized at appositions between somata of enteric neurons immunopositive for the enzyme nitric oxide synthase. There is indication for a possible functional role of gap junctions between inhibitory nitrergic enteric neurons. (c) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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