期刊
FEBS LETTERS
卷 588, 期 9, 页码 1562-1570出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2014.02.039
关键词
Nasopharyngeal carcinoma; Epstein-Barr virus; Latent membrane protein 1; miR-204; Cdc42; Stat-3
资金
- Guangzhou Medical University [2013C61]
Nasopharayngeal carcinoma (NPC) is an Epstein-Barr virus (EBV)-associated malignancy. It is known that microRNAs are implicated in the progression of NPC. However, the role of miR-204 in NPC is poorly understood. In this study, we found that miR-204 was down-regulated in NPC cells and tissues. Low-level expression of miR-204 was significantly associated with a more aggressive and poor prognostic phenotype of NPC. We further found that EBV-encoded latent membrane protein 1 (LMP-1) suppressed miR-204 expression by activating Stat-3. Cdc42 was identified as a direct target of miR-204. Mir-204 inhibited EBV positive C666-1 cell invasion and metastasis partly through targeting cdc42. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据