期刊
FEBS LETTERS
卷 588, 期 4, 页码 600-607出版社
WILEY
DOI: 10.1016/j.febslet.2013.12.028
关键词
Gastric cancer; MicroRNA-106a; Metastasis; Tissue inhibitor of metalloproteinase 2; Matrix metalloproteinase 2
资金
- Ningxia Natural Science Foundation of China [NZ1230]
Emerging evidence has shown that microRNA plays an important role in tumor development and progression. Here, we report that miR-106a is frequently up-regulated in gastric cancer tissues and positively correlates with metastasis. Restrained expression of miR-106a in gastric cancer cells significantly reduces their capacity of proliferation, migration and invasion. In tissue sections, the positive signal of miR-106a localized in metastasis-associated regions confirmed this result. Moreover, we show that TIMP2 is a direct downstream target for miR-106a and knockdown of TIMP2 strengthens the beneficial effects of miR-106a. Our study adds miR-106a to the complex mechanisms of tumor metastasis. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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