期刊
FEBS LETTERS
卷 588, 期 12, 页码 2055-2062出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2014.04.036
关键词
Gastric cancer; miRNA; miR-17-92; Proliferation; SOCS6
资金
- National Basic Research Program of China [2010CB732400, 2010CB529300]
- National Natural Science Foundation of China [81172062, 81030044, 81201632]
This study aimed to test the exact functions and potential mechanisms of miR-17-5p in gastric cancer. Using real-time PCR, miR-17-5p was found to be expressed more highly in gastric cancer compared with-normal tissues. Gain- and loss-of-function assays demonstrated that miR-17-5p increased the proliferation and growth of gastric cancer cells in vitro and in vivo. Through reporter gene and western blot assays, SOCS6 was shown to be a direct target of miR-17-5p, and proliferative assays confirmed that SOCS6 exerted opposing function to that of miR-17-5p in gastric cancer. In short, miR-17-5p might function as a pro-proliferative factor by repressing SOCS6 in gastric cancer. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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