期刊
FEBS LETTERS
卷 588, 期 4, 页码 594-599出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2013.12.027
关键词
Arylalkylamine N-acyltransferase; Arylalkylamine N-acetyltransferase; N-acyldopamine; N-acylserotonin; Thorax-abdomen; Steady-state kinetics; Drosophila melanogaster
资金
- National Institutes of Health [R03-DA034323]
- Florida Center for Excellence for Biomolecular Identification and Targeted Therapeutics (FCoE-BITT Grant) [GALS020]
- Mass Spectrometry and Peptide Facility, Department of Chemistry, University of South Florida
Arylalkylamine N-acyltransferase-like 22 (AANATL2) from Drosophila melanogaster was expressed and shown to catalyze the formation of long-chain N-acylserotonins and N-acydopamines. Subsequent identification of endogenous amounts of N-acylserotonins and colocalization of these fatty acid amides and AANATL2 transcripts gives supporting evidence that AANATL2 has a role in the biosynthetic formation of these important cell signalling lipids. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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