期刊
FEBS LETTERS
卷 588, 期 6, 页码 956-961出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2014.01.054
关键词
Mannan binding lectin; Complement system; Chagas disease; Inate immunity; Parasite-host cell interaction
资金
- Progama Nacional de Parasitologia-Capes-Brazil
To produce an infection Trypanosoma cruzi must evade lysis by the complement system. During early stages of infection, the lectin pathway plays an important role in host defense and can be activated by binding of mannan-binding lectin (MBL) to carbohydrates on the surface of pathogens. We hypothesized that MBL has a dual role during parasite-host cell interaction as lectin complement pathway activator and as binding molecule to invade the host cell. We used two polarized strains of T. cruzi, R4 (susceptible) and 860 (resistant) strains, to investigate the role of MBL in complement-mediated lysis. Interestingly R4, but not 860 metacyclic strain, markedly increases the invasion of host cells, suggesting that MBL drives the invasion process while the parasite deactivates the Lectin complement pathway. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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