期刊
FEBS LETTERS
卷 589, 期 3, 页码 407-413出版社
WILEY
DOI: 10.1016/j.febslet.2014.12.027
关键词
miR-374a; SRC kinase signaling inhibitor 1; Gastric cancer
资金
- National High Technology Research and Development Program of China ''863 Program'' [2014AA020801]
- Shanghai Committee of Science and Technology [124119a3602]
MicroRNAs (miRNAs) play a prominent role in gastric cancer (GC) initiation and progression. In this study, we found that miR-374a expression was up-regulated in human GC cell lines and tissues. Inhibition of miR-374a suppressed GC cell proliferation, migration and invasion in vitro and slowed tumor growth in vivo. SRC kinase signaling inhibitor 1 (SRCIN1) was identified as a direct target of miR-374a. Silencing of SRCIN1 significantly enhanced cell proliferation, migration and invasion, whereas SRCIN1 reintroduction partially abrogated the oncogenic effects of miR-374a. Taken together, these findings suggest that miR-374a functions as a candidate oncogene in GC by directly targeting SRCIN1. miR-374a may therefore be useful as a promising therapeutic target for malignant GC. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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