期刊
FEBS LETTERS
卷 588, 期 18, 页码 3311-3321出版社
WILEY
DOI: 10.1016/j.febslet.2014.07.037
关键词
Selenoprotein K; Peroxidase; Selenocysteine; Diselenide bond; Phospholipid hydroperoxide
资金
- National Institute for General Medical Sciences [P30 GM103519]
- National Science Foundation [MCB-1054447]
- Direct For Biological Sciences
- Div Of Molecular and Cellular Bioscience [1054447] Funding Source: National Science Foundation
Selenoprotein K (SelK) is a membrane protein involved in antioxidant defense, calcium regulation and the ER-associated protein degradation pathway. We found that SelK exhibits a peroxidase activity with a rate that is low but within the range of other peroxidases. Notably, SelK reduced hydrophobic substrates, such as phospholipid hydroperoxides, which damage membranes. Thus, SelK might be involved in membrane repair or related pathways. SelK was also found to contain a diselenide bond-the first intramolecular bond of that kind reported for a selenoprotein. The redox potential of SelK was -257 mV, significantly higher than that of diselenide bonds in small molecules or proteins. Consequently, SelK can be reduced by thioredoxin reductase. These finding are essential for understanding SelK activity and function.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据