期刊
FEBS LETTERS
卷 588, 期 23, 页码 4268-4278出版社
WILEY
DOI: 10.1016/j.febslet.2014.10.007
关键词
Multi-aminoacyl-tRNA synthetase complex; Unicellular; AIMP; GST-like domain; WHEP domain; EMAPII domain; Assembly mode; Evolution
资金
- French National Program Investissement d'Avenir'' [ANR-10-IDEX-0002-02]
- University of Strasbourg
- CNRS
- MitoCross'' Labex Investissements d'Avenir'' program [ANR-10-IDEX-0002-02]
- IDEX Unistra postdoctoral fellowship
- Ministere de l'Education Nationale, de la Recherche et de la Technologie
- Agence Nationale de la Recherche (ANR) [ANR-10-IDEX-0002] Funding Source: Agence Nationale de la Recherche (ANR)
Aminoacyl-tRNA synthetases (aaRSs) are ubiquitous and ancient enzymes, mostly known for their essential role in generating aminoacylated tRNAs. During the last two decades, many aaRSs have been found to perform additional and equally crucial tasks outside translation. In metazoans, aaRSs have been shown to assemble, together with non-enzymatic assembly proteins called aaRSs-interacting multifunctional proteins (AIMPs), into so-called multi-synthetase complexes (MSCs). Metazoan MSCs are dynamic particles able to specifically release some of their constituents in response to a given stimulus. Upon their release from MSCs, aaRSs can reach other subcellular compartments, where they often participate to cellular processes that do not exploit their primary function of synthesizing aminoacyl-tRNAs. The dynamics of MSCs and the expansion of the aaRSs functional repertoire are features that are so far thought to be restricted to higher and multicellular eukaryotes. However, much can be learnt about how MSCs are assembled and function from apparently 'simple' organisms. Here we provide an overview on the diversity of these MSCs, their composition, mode of assembly and the functions that their constituents, namely aaRSs and AIMPs, exert in unicellular organisms. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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