期刊
FEBS LETTERS
卷 588, 期 5, 页码 757-763出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2014.01.022
关键词
MiR-874; Aquaporin; Intestinal barrier; Intestinal ischemia
资金
- National Natural Science Foundation of China [30901421]
- Science and Education for Health Foundation of Jiangsu Province [XK03 200903]
Intestinal ischemic injury is a significant clinical problem arising from diseases or as a complication of abdominal surgery. Our previous study showed aquaporin 3 is involved in intestinal barrier impairment. Here, we revealed that intestinal ischemia induced a time-dependent increase of miR-874 expression and a time-dependent decrease of AQP3 expression, and the level of miR-874 expression was inversely related to AQP3 protein expression. In addition, miR-874 promoted the paracellular permeability in vitro through targeting 3 ' UTR of AQP3. Two of the tight junction proteins, Occludin and Claudin-1, were found to be involved in miR-874-induced intestinal barrier dysfunction. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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