期刊
FEBS LETTERS
卷 588, 期 13, 页码 2162-2169出版社
WILEY
DOI: 10.1016/j.febslet.2014.04.050
关键词
Cancer associated fibroblasts; microRNA; Protein tyrosine phosphatase and tensin homologue; Gastric cancer
资金
- National Science Foundation of China [C30672046]
It is well established that the interaction between cancer cells and microenvironment has a critical role in tumor development, but the roles of miRNAs in this interaction are rarely known. Here, we have shown that miR-106b is up-regulated in cancer associated fibroblasts compared with normal fibroblasts established from patients with gastric cancer, the expression level of miR-106b is associated with poor prognosis of patients, and CAFs with down-regulated miR-106b could significantly inhibit gastric cancer cell migration and invasion by targeting PTEN. Taken together, these data suggest that miR-106b might be a novel candidate target for the treatment of gastric cancer. (C) 2014 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
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