期刊
FEBS LETTERS
卷 588, 期 10, 页码 1857-1868出版社
WILEY
DOI: 10.1016/j.febslet.2014.04.023
关键词
Transportin; Importins; Karyopherins; Nuclear import; Nucleo-cytoplasmic transport; NLS; Kap104p; Transportin-1; Transportin-2; Karyopherin-beta 2; hnRNP A1; FUS
资金
- Fund for Medical Scientific Research (Belgium) [2.4.511.00.F]
- Fonds Brachet
- Fonds Van Buuren
- Actions de Recherches Concertees'' [AV. 06/11-345]
- FEDER program of the Walloon region
Nearly 20 years after its identification as a new beta-karyopherin mediating the nuclear import of the RNA-binding protein hnRNP A1, Transportin-1 is still commonly overlooked in comparison with its best known cousin, Importin-beta. Transportin-1 is nonetheless a considerable player in nucleo-cytoplasmic transport. Over the past few years, significant progress has been made in the characterization of the nuclear localization signals (NLSs) that Transportin-1 recognizes, thereby providing the molecular basis of its diversified repertoire of cargoes. The recent discovery that mutations in the Transportin-dependent NLS of FUS cause mislocalization of this protein and result in amyotrophic lateral sclerosis illustrates the importance of Transportin-dependent import for human health. Besides, new functions of Transportin-1 are emerging in processes other than nuclear import. Here, we summarize what is known about Transportin-1 and the related beta-karyopherin Transportin-2. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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