期刊
FEBS LETTERS
卷 588, 期 9, 页码 1787-1794出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2014.03.039
关键词
Cyanobacteria; Transcriptional regulation
资金
- Ministerio de Ciencia e Innovacion (Spain) - FEDER [BFU2010-17980]
In Anabaena, the pipX gene is induced in the cells differentiating into heterocysts, being the PipX factor required for full expression of late heterocyst-specific genes. Here we show that PipX has a positive effect on in vitro binding of the transcription factor NtcA to DNA, as well as on transcript production, in different NtcA-dependent promoters. We found that the cox3 operon, encoding a heterocyst-specific terminal respiratory oxidase, is expressed from three nitrogen-regulated promoters to which NtcA binds. At the three sites, NtcA binding is potentiated by PipX. Thus, PipX has a direct effect on gene expression influencing the activity of NtcA. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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