期刊
FEBS LETTERS
卷 588, 期 10, 页码 1899-1905出版社
WILEY
DOI: 10.1016/j.febslet.2014.04.018
关键词
Hikeshi; Opi10; Hsp70; Heat shock; Nuclear transport; Schizosaccharomyces pombe
资金
- Japan Society for the Promotion of Science (JSPS)
- Grants-in-Aid for Scientific Research [23570242] Funding Source: KAKEN
Human Hikeshi (HsHikeshi) is a nuclear import carrier for Hsp70s and is required for cell survival after heat shock. The Hikeshi homolog in Schizosaccharomyces pombe (SpHikeshi/Opi10) localizes to the nuclear rim, interacts with the Hsp70 homolog Ssa2, and mediates its nuclear import in a reconstituted mammalian nuclear transport system. However, SpHikeshi/Opi10 is not required for heat stress response and survival after heat stress. Instead, SpHikeshi/Opi10 is required for the normal expression of stress response genes under optimal conditions and for cell growth during glucose deprivation. Here, the functions of SpHikeshi/Opi10 are discussed and compared to the functions of HsHikeshi.
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