期刊
FEBS LETTERS
卷 587, 期 11, 页码 1687-1692出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2013.04.019
关键词
Calcium cycling; Energy expenditure; Skeletal muscle
资金
- Canadian Institutes of Health Research [MOP 86618, MOP 47296]
- Natural Sciences and Engineering Research Council of Canada
- Canadian Institutes of Health Research
The purpose of this study was to examine the effects of sarcolipin (SLN) on sarco(endo) plasmic reticulum Ca2+-ATPase (SERCA pump) energetics in vivo and resting skeletal muscle metabolic rate. Using SLN knockout (Sln(-/-)) mice we show that SLN ablation increases the transport stoichiometry of SERCA pumps (Ca2+ uptake/Ca2+-ATPase activity) and decreases the relative contribution of SERCA pumps to resting oxygen consumption (VO2) in soleus without affecting soleus or whole body VO2. These data suggest that the lower energy requirements for Ca2+ cycling in resting skeletal muscle of Sln(-/-) mice do not impact significantly either skeletal muscle or whole body metabolic rate. (c) 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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