期刊
FEBS LETTERS
卷 587, 期 10, 页码 1489-1495出版社
WILEY
DOI: 10.1016/j.febslet.2013.03.013
关键词
Histone acetyltransferase; Atac2; Intestinal stem cell; Drosophila
资金
- VDRC
- NIG-Fly
- Bloomington Drosophila Stock Center and University of Iowa Developmental Studies Hybridoma Bank for flies and reagents
One of the major challenges in stem cell research is to decipher the controlling mechanisms/genes of stem cell homeostasis. Through an RNAi mediated genetic screen of living animals, we identified an evolutionarily conserved histone acetyltransferase Atac2 as a novel regulator of Drosophila intestinal stem cells (ISCs). Expression of Atac2-RNAi or a dominant negative allele of Atac2 generated more ISCs, while excessive Atac2 or a histone deacetylase inhibitor promoted ISC differentiation without affecting ISC survival or lineage specification. These findings extend our knowledge of epigenetic mechanisms in stem cell regulation.
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