期刊
FEBS LETTERS
卷 587, 期 17, 页码 2818-2824出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2013.06.025
关键词
Substrate competition; Kinetic rate laws; Modelling; Metabolic pathway
资金
- Research Council of Norway through the Norwegian-German Collaboration Support Scheme [191721]
- eVITA program [178885/V30]
- German Federal Ministry of Education and Research [BMBF] within the Research Initiative in Systems Biology of Ageing (GerontoSys) [0315591D, 0315890C]
- German academic exchange service (DAAD) within the German-Norwegian Collaborative Research Support Scheme
Substrate competition can be found in many types of biological processes, ranging from gene expression to signal transduction and metabolic pathways. Although several experimental and in silico studies have shown the impact of substrate competition on these processes, it is still often neglected, especially in modelling approaches. Using toy models that exemplify different metabolic pathway scenarios, we show that substrate competition can influence the dynamics and the steady state concentrations of a metabolic pathway. We have additionally derived rate laws for substrate competition in reversible reactions and summarise existing rate laws for substrate competition in irreversible reactions. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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