期刊
FEBS LETTERS
卷 587, 期 8, 页码 1180-1188出版社
WILEY
DOI: 10.1016/j.febslet.2013.03.002
关键词
RNA structure; Riboswitch; Frameshifting; IRES; Translation
资金
- American Cancer Society [PF-11-172-01-RMC]
- Ruth L. Kirschstein National Research Service Award [F32 GM 101696-1]
- NIH [AI068462]
- NSF [MCB-1121024]
- Direct For Biological Sciences
- Div Of Molecular and Cellular Bioscience [1121024] Funding Source: National Science Foundation
Structured RNA elements within messenger RNA often direct or modulate the cellular production of active proteins. As reviewed here, RNA structures have been discovered that govern nearly every step in protein production: mRNA production and stability; translation initiation, elongation, and termination; protein folding; and cellular localization. Regulatory RNA elements are common within RNAs from every domain of life. This growing body of RNA-mediated mechanisms continues to reveal new ways in which mRNA structure regulates translation. We integrate examples from several different classes of RNA structure-mediated regulation to present a global perspective that suggests that the secondary and tertiary structure of RNA ultimately constitutes an additional level of the genetic code that both guides and regulates protein biosynthesis. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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