期刊
FEBS LETTERS
卷 587, 期 14, 页码 2241-2246出版社
WILEY
DOI: 10.1016/j.febslet.2013.05.053
关键词
Neutrophil extracellular trap; Innate immunity; Diabetes; Interleukin-6; Hyperglycemia
资金
- TIFAC-CORE in Pharmacogenomics
- Department of Biotechnology, Government of India
- Manipal University, Manipal, India
Neutrophils serve as an active constituent of innate immunity and are endowed with distinct ability for producing neutrophil extracellular traps (NETs) to eliminate pathogens. Earlier studies have demonstrated a dysfunction of the innate immune system in diabetic subjects leading to increased susceptibility to infections; however, the influence of hyperglycemic conditions on NETs is unknown. In the present study we demonstrate that (a) NETs are influenced by glucose homeostasis, (b) IL-6 is a potent inducer of energy dependent NET formation and (c) hyperglycemia mimics a state of constitutively active pro-inflammatory condition in neutrophils leading to reduced response to external stimuli making diabetic subjects susceptible to infections. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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