期刊
FEBS LETTERS
卷 587, 期 23, 页码 3875-3882出版社
WILEY
DOI: 10.1016/j.febslet.2013.10.023
关键词
Bladder cancer; MicroRNA; Hsa-miR-125b; SIRT7; Long non-coding RNA; MALAT1
资金
- China Postdoctoral Science Foundation [2013M542227]
- National Natural Science Foundation of China [81372735]
- National Basic Research Program of China (973 Program) [2014CB745200]
- Basic Research Program of Shenzhen [ZDSY20120615154448514]
MicroRNAs mainly inhibit coding genes and long non-coding RNA expression. Here, we report that hsa-miR-125b and oncogene SIRT7/oncogenic long non-coding RNA MALAT1 were inversely expressed in bladder cancer. Hsa-miR-125b mimic down-regulated, whereas hsa-miR-125b inhibitor up-regulated the expression of SIRT7 and MALAT1. Binding sites were confirmed between hsamiR- 125b and SIRT7/MALAT1. Up-regulation of hsa-miR-125b or down-regulation of SIRT7 inhibited proliferation, motility and increased apoptosis. The effects of up-regulation of hsa-miR-125b were similar to that of silencing MALAT1 in bladder cancer as we had previously described. These data suggest that hsa-miR-125b suppresses bladder cancer development via inhibiting SIRT7 and MALAT1. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据