期刊
FEBS LETTERS
卷 587, 期 10, 页码 1556-1561出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2013.03.040
关键词
Adiponectin; MicroRNA; Macrophage; PDCD4; Paracrine
资金
- Yeungnam University
MicroRNA-21 and programmed cell death 4 (PDCD4), a downstream target of miR-21, mediate diverse physiological responses. Here we demonstrate that globular adiponectin (gAcrp) modulates expression of miR-21 and PDCD4 in RAW 264.7 macrophages. These effects were abrogated by inhibitors of ERK1/2, JNK or NF-kappa B. Conditioned media collected from gAcrp-stimulated RAW 264.7 macrophages caused similar effects as direct gAcrp treatment, showing the paracrine effect of gAcrp. These data indicate that gAcrp modulates the miR-21/PDCD4 axis through the ERK and JNK/NF-kappa B pathways in RAW 264.7 macrophages and further suggest that the miR-21/PDCD4 axis may be a novel target mediating adiponectin-induced biological responses. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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