期刊
FEBS LETTERS
卷 587, 期 6, 页码 645-651出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2013.01.019
关键词
HBx; Hepatocellular carcinoma; Complement-dependent cytotoxicity; CD46; Immune escape
资金
- National Basic Research Program of China (973 Program) [2009CB521702]
- National Natural Science Foundation of China [81071624, 81272218]
- National Science and Technology of China [2012BAI23B08]
The involvement of hepatitis B virus X protein (HBx) in anti-complement-dependent cytotoxicity (CDC) activity during hepatocarcinogenesis is poorly understood. Here, we report that HBx is able to up-regulate membrane-bound complement regulatory protein CD46 in hepatoma cells and human immortalized liver cells through activating the promoter activity involving cAMP response element-binding protein (CREB)/cyclooxygenase-2(COX-2)/prostaglandin E2 (PGE2)/signal transducers and activators of transcription 3 (STAT3) signaling pathway. In contrast, the down-regulation of CD46 abolishes the resistance capability of hepatoma cells to CDC. Thus, we conclude that HBx contributes to the protection of hepatoma and hepatic cells from CDC by up-regulation of CD46. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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