期刊
FEBS LETTERS
卷 587, 期 12, 页码 1711-1716出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2013.04.034
关键词
Methionine adenosyltransferase; S-adenosylmethionine; Methylation; Redox regulation; Association state; Epigenetic modification
资金
- Ministerio de Economia y Competitividad [BFU2008-00666, BFU2009-08977, SAF2009-11642, SAF2012-36519]
- Instituto de Salud Carlos III [RETICS RD12/0013/0008, FIS PI12/01196]
S-adenosylmethionine synthesis is a key process for cell function, and needs to be regulated at multiple levels. In recent years, advances in the knowledge of methionine adenosyltransferases have been significant. The discovery of nuclear localization of these enzymes suggests their transport to provide the methyl donor, S-adenosylmethionine, for DNA and histone methyltransferases in epigenetic modifications, opening new regulatory possibilities. Previous hypotheses considered only the cytoplasmic regulation of these enzymes, hence the need of an update to integrate recent findings. Here, we focus mainly on the liver and redox mechanisms, and their putative effects on localization and interactions of methionine adenosyltransferases. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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