期刊
FEBS LETTERS
卷 587, 期 15, 页码 2448-2454出版社
WILEY
DOI: 10.1016/j.febslet.2013.06.015
关键词
Alzheimer's; Astrocyte; PEA-15; TgCRND8; Human
资金
- Ontario Graduate Scholarship
- Heart and Stroke Foundation Centre for Stroke Recovery Trainee Stimulus Fellowship
- Canadian Institutes of Health Research
- CIHR [MOP-10246]
- Botterell Foundation of Queen's University
To identify potential biomarkers associated with Alzheimer's disease (AD)-like neuropathologies in the murine brain, we conducted proteomic analyses of neocortices from TgCRND8 mice. Here we found that phosphoprotein enriched in astrocytes 15 kDa (PEA-15) is expressed at higher levels in the neocortical proteomes from 6-month old TgCRND8 mice, as compared to non-transgenic mice. Immunostaining for PEA-15 revealed reactive astrocytes associated with the neocortical amyloid plaques in TgCRND8 mice and in post-mortem human AD brains. This is the first report of increased PEA-15 expression in reactive astrocytes of an AD mouse model and human AD brains. (C) 2013 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
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