期刊
FEBS LETTERS
卷 587, 期 24, 页码 3979-3985出版社
WILEY
DOI: 10.1016/j.febslet.2013.10.033
关键词
NMR; Molecular dynamic; CEP; Root-knot nematode; Peptide; CLE; Meloidogyne
资金
- NSF [IOS 1025840, IOS-0840932]
- Australian Research Council [DP120101893]
- USDA NIFA
- Division Of Integrative Organismal Systems
- Direct For Biological Sciences [1025840] Funding Source: National Science Foundation
The C-terminally Encoded Peptide (CEP) family of regulatory peptides controls root development in vascular plants. Here, we present the first NMR structures of CEP. We show that root-knot nematode (RKN: Meloidogyne spp.) also encodes CEP, presumably to mimic plant CEP as part of their stereotypic, parasitic interaction with vascular plants. Molecular dynamics simulations of plant- and nematode-encoded CEP displaying known posttranslational modifications (PTM) provided insight into the structural effects of PTM and the conformational plasticity and rigidity of CEP. Potential mechanisms of action are discussed with respect to the structure and sampling of conformational space. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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