期刊
FEBS LETTERS
卷 587, 期 22, 页码 3722-3728出版社
WILEY
DOI: 10.1016/j.febslet.2013.09.042
关键词
O-GlcNAc; Tau; Site-specific; Monoclonal antibody; OGA
Aggregation of tau into paired helical filaments is a pathological process leading to neurotoxicity in Alzheimer's disease and other tauopathies. Tau is posttranslationally modified by O-linked N-acetylglucosamine (O-GlcNAc), and increasing tau O-GlcNAcylation may protect against its aggregation. Research tools to study the relationship between tau aggregation and tau O-GlcNAcylation have not been widely available. Here we describe the generation of a rabbit monoclonal antibody specific for tau O-GlcNAcylated at Ser400 (O-tau(S400)). We show the utility of this antibody for in vitro and in vivo experiments to investigate the function of O-GlcNAc modifications of tau at Ser400. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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