期刊
FEBS LETTERS
卷 587, 期 23, 页码 3869-3874出版社
WILEY
DOI: 10.1016/j.febslet.2013.10.022
关键词
Diabetes; Protein phosphatase 5; High-fat diet; Knockout mouse; Obesity; Insulin sensitivity
资金
- Swedish Diabetes Foundation
- Olle Engkvist Byggmastare Foundation
- Diabetes Research and Wellness Foundation
- Berth von Kantzow's Foundation
- Tornspiran Foundation
- Golje's Memorial Foundation
- Swedish Society for Medical Research
The role of serine/threonine protein phosphatase 5 (PP5) in the development of obesity and insulin resistance associated with high-fat diet-feeding (HFD) was examined using PP5-deficient mice (Ppp5c(-/-)). Despite similar caloric intake, Ppp5c(-/-) mice on HFD gained markedly less weight and did not accumulate visceral fat compared to wild-type littermates (Ppp5c(+/+)). On a control diet, Ppp5c(-/-) mice had markedly improved glucose control compared to Ppp5c(+/+) mice, an effect diminished by HFD. However, even after 10 weeks of HFD glucose control in Ppp5c(-/-) mice was similar to that observed in Ppp5c(+/+) mice on the control diet. Thus, PP5 deficiency confers protection against HFD-induced weight gain in mice. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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