期刊
FEBS LETTERS
卷 587, 期 2, 页码 156-164出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2012.11.010
关键词
RNase L, 2 ',5 '-Oligoadenylate synthetase; Hepatitis C virus; Antiviral protein
资金
- National Research Foundation of the Republic of Korea [2012-008126]
- Ministry of Education, Science & Technology of Korea
The latent ribonuclease RNase L and the interferon-inducible 2',5'-oligoadenylate synthetase (OAS) have been implicated in the antiviral response against hepatitis C virus (HCV). However, the specific roles of these enzymes against HCV have not been fully elucidated. In this study, a scarce endogenous expression and RNA degrading activity of RNase L in human hepatoma Huh7 cells enabled us to demonstrate the antiviral activity of RNase L against HCV replication through the transient expression of the enzyme. The antiviral potential of specific members of the OAS family was further examined through overexpression and RNA interference approaches. Our data suggested that among the members of the OAS family, OAS1 p46 and OAS3 p100 mediate the RNase L-dependent antiviral activity against HCV. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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