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CELL (2011)
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CELL (2011)
Regulation of DNA Replication through Sld3-Dpb11 Interaction Is Conserved from Yeast to Humans
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CURRENT BIOLOGY (2011)
CDK prevents Mcm2-7 helicase loading by inhibiting Cdt1 interaction with Orc6
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Idas, a Novel Phylogenetically Conserved Geminin-related Protein, Binds to Geminin and Is Required for Cell Cycle Progression
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GINS and Sld3 Compete with One Another for Mcm2-7 and Cdc45 Binding
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JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
MCM2-7 Form Double Hexamers at Licensed Origins in Xenopus Egg Extract
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JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Highly stable loading of Mcm proteins onto chromatin in living cells requires replication to unload
Marjorie A. Kuipers et al.
JOURNAL OF CELL BIOLOGY (2011)
Direct regulation of Treslin by cyclin-dependent kinase is essential for the onset of DNA replication
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JOURNAL OF CELL BIOLOGY (2011)
Dynamic recruitment of licensing factor Cdt1 to sites of DNA damage
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JOURNAL OF CELL SCIENCE (2011)
Mutations in origin recognition complex gene ORC4 cause Meier-Gorlin syndrome
Duane L. Guernsey et al.
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Mutations in ORC1, encoding the largest subunit of the origin recognition complex, cause microcephalic primordial dwarfism resembling Meier-Gorlin syndrome
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NATURE GENETICS (2011)
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NATURE GENETICS (2011)
The structural basis for MCM2-7 helicase activation by GINS and Cdc45
Alessandro Costa et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2011)
A quantitative model for cyclin-dependent kinase control of the cell cycle: revisited
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Minichromosome maintenance helicase paralog MCM9 is dispensible for DNA replication but functions in germ-line stem cells and tumor suppression
Suzanne A. Hartford et al.
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How dormant origins promote complete genome replication
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TRENDS IN BIOCHEMICAL SCIENCES (2011)
Eukaryotic Chromosome DNA Replication: Where, When and How?
Hisao Masai et al.
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 79 (2010)
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Treslin Collaborates with TopBP1 in Triggering the Initiation of DNA Replication
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CELL (2010)
Cyclin-dependent kinase-dependent initiation of chromosomal DNA replication
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CURRENT OPINION IN CELL BIOLOGY (2010)
CDK-dependent complex formation between replication proteins Dpb11, Sld2, Pol ε, and GINS in budding yeast
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GENES & DEVELOPMENT (2010)
A vertebrate gene, ticrr, is an essential checkpoint and replication regulator
Christopher L. Sansam et al.
GENES & DEVELOPMENT (2010)
Conserved nucleosome positioning defines replication origins
Matthew L. Eaton et al.
GENES & DEVELOPMENT (2010)
How do Cdc7 and cyclin-dependent kinases trigger the initiation of chromosome replication in eukaryotic cells?
Karim Labib
GENES & DEVELOPMENT (2010)
The DNA Unwinding Element Binding Protein DUE-B Interacts with Cdc45 in Preinitiation Complex Formation
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MOLECULAR AND CELLULAR BIOLOGY (2010)
HBO1 Histone Acetylase Activity Is Essential for DNA Replication Licensing and Inhibited by Geminin
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Dynamic changes in histone acetylation regulate origins of DNA replication
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COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2010)
Concerted Loading of Mcm2-7 Double Hexamers around DNA during DNA Replication Origin Licensing
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CELL (2009)
Poly(dA:dT) tracts: major determinants of nucleosome organization
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CURRENT OPINION IN STRUCTURAL BIOLOGY (2009)
MCM10 mediates RECQ4 association with MCM2-7 helicase complex during DNA replication
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EMBO JOURNAL (2009)
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Jeanette Gowen Cook
FRONTIERS IN BIOSCIENCE-LANDMARK (2009)
Incorporation into the prereplicative complex activates the Mcm2-7 helicase for Cdc7-Dbf4 phosphorylation
Laura I. Francis et al.
GENES & DEVELOPMENT (2009)
Dbf4-Cdc7 Phosphorylation of Mcm2 Is Required for Cell Growth
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JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
The heterochromatin protein Swi6/HP1 activates replication origins at the pericentromeric region and silent mating-type locus
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NATURE CELL BIOLOGY (2009)
A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication
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Quaternary structure of the human Cdt1-Geminin complex regulates DNA replication licensing
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Transcription Initiation Activity Sets Replication Origin Efficiency in Mammalian Cells
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MOLECULAR BIOLOGY OF THE CELL (2008)
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MOLECULAR CELL (2008)
Stochastic hybrid modeling of DNA replication across a complete genome
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Genome-wide studies highlight indirect links between human replication origins and gene regulation
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Distinct Modes of Regulation by Chromatin Encoded through Nucleosome Positioning Signals
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CANCER RESEARCH (2007)
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Cdt1 associates dynamically with chromatin throughout G1 and recruits Geminin onto chromatin
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EMBO JOURNAL (2007)
CDK-dependent phosphorylation of Sld2 and Sld3 initiates DNA replication in budding yeast
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NATURE (2007)
A viable allele of Mcm4 causes chromosome instability and mammary adenocarcinomas in mice
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NATURE GENETICS (2007)
The human GINS complex binds to and specifically stimulates human DNA polymerase alpha-primase
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EMBO REPORTS (2007)
Phosphorylation of MCM4 by Cdc7 kinase facilitates its interaction with Cdc45 on the chromatin
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YEAST (2006)
Cdc7-Dbf4 phosphorylates MCM proteins via a docking site-mediated mechanism to promote S phase progression
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MOLECULAR CELL (2006)
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GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks
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PCNA is a cofactor for Cdt1 degradation by CUL4/DDB1-mediated N-terminal ubiquitination
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EMBO JOURNAL (2006)
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The Chinese hamster dihydrofolate reductase replication origin decision point follows activation of transcription and suppresses initiation of replication within transcription units
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MOLECULAR AND CELLULAR BIOLOGY (2006)
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MOLECULAR CELL (2006)
PCNA functions as a molecular platform to trigger Cdt1 destruction and prevent re-replication
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NATURE CELL BIOLOGY (2006)
Cdt1 transgenic mice develop lymphoblastic lymphoma in the absence of p53
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ONCOGENE (2005)
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DNA REPAIR (2005)
A mutation in Dbf4 motif M impairs interactions with DNA replication factors and confers increased resistance to genotoxic agents
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MOLECULAR AND CELLULAR BIOLOGY (2005)
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MOLECULAR AND CELLULAR BIOLOGY (2004)
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AMERICAN JOURNAL OF PATHOLOGY (2004)
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MOLECULAR AND CELLULAR BIOLOGY (2004)
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Stable chromosomal units determine the spatial and temporal organization of DNA replication
N Sadoni et al.
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Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding
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The SCFSkp2 ubiquitin ligase complex interacts with the human replication licensing factor Cdt1 and regulates Cdt1 degradation
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GINS, a novel multiprotein complex required for chromosomal DNA replication in budding yeast
Y Takayama et al.
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DNA polymerase clamp shows little turnover at established replication sites but sequential de novo assembly at adjacent origin clusters
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Sld3, which interacts with Cdc45 (Sld4), functions for chromosomal DNA replication in Saccharomyces cerevisiae
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SCIENCE (2000)
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