期刊
FEBS LETTERS
卷 586, 期 16, 页码 2459-2467出版社
WILEY
DOI: 10.1016/j.febslet.2012.06.004
关键词
miR-21; IL-12; Mycobacterium; Th1; Dendritic cell; Bcl2
资金
- National Basic Research Program of China (973 program) [2007CB513003]
- Mega-projects of Science Research for the 11th and 12th Five-Year Plan of China, Ministry of Science and Technology [2011ZX10004-901]
miR-21 has been shown to regulate multiple mRNAs and cause tumor progression and metastasis. However, whether miR-21-mediated posttranscriptional regulation is involved in antigen presentation and anti-mycobacterial responses remains unclear. Here, we report that miR-21 can be induced after Bacillus Calmette-Guerin (BCG) vaccination by NF-kB activation. miR-21 suppressed IL-12 production by targeting IL-12p35, which impaired anti-mycobacterial T cell responses both in vitro and in vivo. Additionally, miR-21 also promoted dendritic cell (DC) apoptosis by targeting Bcl-2. Therefore, miR-21 may potentially be involved in fine-tuning of the anti-mycobacterial Th1 response and in regulating the efficacy of BCG vaccination. (c) 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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