期刊
FEBS LETTERS
卷 586, 期 20, 页码 3723-3730出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2012.09.001
关键词
Arachidonic acid; Biomarker; Cyclooxygenase; Glutathione; Oxidative stress; Prostaglandin H synthase
Prostaglandin (PG) H synthases (PGHS) or cyclooxygenases (COX) catalyse the peroxidation of arachidonic acid (AA) to PGG(2) and PGH(2) which are further converted to a series of prostaglandins and thromboxane A(2). Here, we report that GSH promotes concomitant formation of the current oxidative stress biomarkers malondialdehyde (MDA) and 15(S)-8-iso-prostaglandin F-2 alpha from AA via PGHS. This illustrates an uncommon interplay of enzymatic and chemical reactions to produce species that are considered to be exclusively produced by free-radical-catalysed reactions. We propose mechanisms for the PGHS/AA/GSH-dependent formation of MDA, 15(S)-8-iso-prostaglandin F-2 alpha and other F-2-isoprostanes. These mechanisms are supported by clinical observations. (c) 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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