期刊
FEBS LETTERS
卷 586, 期 19, 页码 3349-3353出版社
WILEY
DOI: 10.1016/j.febslet.2012.07.017
关键词
Reelin; Brain; Protease; ADAMTS; Processing
资金
- Ministry of Education, Culture, Sports, Science and Technology [22390016, 23123519, 22890155]
- Takeda Science Foundation
- Grants-in-Aid for Scientific Research [23123519, 22890155, 22390016] Funding Source: KAKEN
Reel in is a glycoprotein essential for brain development and functions. Reelin is subject to specific proteolysis at two distinct (N-t and C-t) sites, and these cleavages significantly diminish Reelin activity. The decrease of Reelin activity is detrimental for brain function, but the protease that catalyzes specific cleavage of Reelin remains elusive. Here we found that a disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4) cleaves Reelin in an isoform-specific manner. Among ADAMTS-4 isoforms, p50 cleaves the N-t site only, while p75 cleaves both sites. This is the first report identifying a protease that can specifically cleave Reelin. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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