期刊
FEBS LETTERS
卷 587, 期 2, 页码 238-244出版社
WILEY
DOI: 10.1016/j.febslet.2012.11.032
关键词
Astrocyte; PrPC over-expression; STI1; Differentiation; GFAP; Survival
资金
- FAPESP (Fundacao de Amparo a Pesquisa do Estado de Sao Paulo) [03-13189-2, 09/14027-2]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [03/13189-2, 09/14027-2] Funding Source: FAPESP
Prion protein (PrPC) has neuroprotective functions and herein we demonstrate that astrocytes from PrPC-over-expressing mice are more resistant to induced cell death than wild-type astrocytes. The Stress-Inducible-Protein 1 (STI1), a PrPC ligand, prevents cell death in both wild-type and PrPC-over-expressing astrocytes through the activation of protein-kinase-A. Cultured embryonic astrocytes and brain extracts from PrPC-over-expressing mice show higher glial fibrillary acidic protein expression and reduced vimentin and nestin levels when compared to wild-type astrocytes, suggesting faster astrocyte maturation in the former mice. Our data indicate that PrPC levels modulate astrocyte development, and that PrPC-STI1 interaction contributes to protect against astrocyte death. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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