期刊
FEBS LETTERS
卷 586, 期 7, 页码 1032-1037出版社
WILEY
DOI: 10.1016/j.febslet.2012.02.047
关键词
Dengue; PrM; M Protein; Localisation; Endoplasmic reticulum; Oligomerisation
资金
- National Health and Medical Research Council of Australia
- University of Melbourne
The dengue virus membrane (M) protein is a key component of the mature virion. Here, we characterised the cellular behaviour of M using a recombinant protein construct to understand its inherent properties. Using confocal microscopy, we showed that M and its intracellular precursor, prM, localised to the endoplasmic reticulum. M protein was also detected on the cell surface and secreted, suggesting that M can enter the secretory pathway. In addition, cross-linking studies showed that M can form dimers and tetramers. These findings suggest that M behaves as a secretory protein analogous to the major envelope protein E. Crown Copyright (C) 2012 Published by Elsevier B. V. on behalf of Federation of European Biochemical society. All rights reserved.
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