期刊
FEBS LETTERS
卷 586, 期 4, 页码 289-295出版社
WILEY
DOI: 10.1016/j.febslet.2012.01.036
关键词
Budding yeast; Phosphate homeostasis; SPX domain; Phosphate starvation; Saccharomyces cerevisiae
资金
- Australian Research Council [FS100100022]
- Key Basic Research Special Foundation of China [2011CB100303]
- Science and Technology Cooperation Project of China and Australia [20080242]
- Australian Research Council [FS100100022] Funding Source: Australian Research Council
In the yeast Saccharomyces cerevisiae, a working model for nutrient homeostasis in eukaryotes, inorganic phosphate (Pi) homeostasis is regulated by the PHO pathway, a set of phosphate starvation induced genes, acting to optimize Pi uptake and utilization. Among these, a subset of proteins containing the SPX domain has been shown to be key regulators of Pi homeostasis. In this review, we summarize the recent progresses in elucidating the mechanisms controlling Pi homeostasis in yeast, focusing on the key roles of the SPX domain-containing proteins in these processes, as well as describing the future challenges and opportunities in this fast-moving field. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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