期刊
FEBS LETTERS
卷 586, 期 4, 页码 435-441出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2012.01.026
关键词
RUVBL2; ARF; p53; Transcription repression
资金
- National Natural Science Foundation of China [30871290, 31030046, 31171316]
- Ministry of Science and Technology of China [2010CB912804, 2011CBA01103, 2011CB966302]
- Ph.D. Programs Foundation of Ministry of Education of China [200803580063]
ARF is the second most commonly inactivated tumor suppressor behind p53. It has been implicated in the control of cell proliferation, cell senescence, and tumor suppression. However, the detailed mechanism underlying the transcriptional control of ARF remains largely unknown. Here we report RUVBL2 as a novel transcriptional repressor of ARF. Ectopic expression of RUVBL2 decreases the levels of ARF, whereas knockdown of RUVBL2 results in a marked increase in ARF levels. In addition, RUVBL2 down-regulates the levels of p53 in an ARF-dependent manner. Mechanistically, RUVBL2 binds to the distal region of ARF promoter, thus leading to the repression of ARF transcription. These results suggest an important role of RUVBL2 in the regulation of ARF-p53 pathway. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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