期刊
FEBS LETTERS
卷 586, 期 7, 页码 996-1003出版社
WILEY
DOI: 10.1016/j.febslet.2012.02.027
关键词
Cardiac energy metabolism; High fat diet; E2F1; Pyruvate dehydrogenase kinase 4; Cyclin D1
资金
- Heart and Stroke Foundation of Alberta
- AHFMR
- Mazankowski Alberta Heart Institute
A high fat diet (HFD) induces substantial cardiac metabolic alteration(s), but the initiating molecular events remain unclear. We assessed the early cardiac energy metabolic changes in C57/BJ mice fed a HFD for 10 days. Carbohydrate oxidation was markedly decreased in mice on a HFD, in which up-regulation of pyruvate dehydrogenase kinase 4 (PDK4) was evident. Concurrently, E2F1, a transcription factor controlling PDK4 expression, was activated, as was cyclin D1, an upstream-molecule of E2F1, and eukaryotic initiation factor 4E (eIF4E), a modulator of cyclinD1 translation. Hence, HFD may initiate early cardiac metabolic alterations through the eIF4E/cyclin D1/E2F1/PDK4 axis. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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